Occurs when the ovaries stop functioning normally before age 40
Aetiology
- Idiopathic
- Genetic (Turner's syndrome, fragile X)
- Chemotherapy, radiotherapy
- Oophorectomy
Clinical presentation
- Hot flushes
- Night sweats
- Atophic vaginitis
- Amenorrhoea
- Infertility
Investigations
Endocrine features
- High FSH
- High LH
- Low oestradiol
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