Mixed Connective Tissue Disease

Uncommon, specifically defined condition which features symptoms also seen in other connective tissue diseases

Clinical presentation

  • Raynaud’s
  • Arthralgia/arthritis
  • Myositis
  • Sclerodactyly
  • Pulmonary hypertension
  • ILD

Investigations

  • Antibodies - associated with anti-RNP antibodies

Management

  • Varies according to presentation
  • CCBs may be helpful for Raynaud’s
  • If there is significant muscle or lung disease immunosuppression may be required
  • Monitoring - patients should be monitored for pulmonary hypertension (anual echo) and ILD (PFTs)