Recurrent Miscarriage

3 or more pregnancy losses

Aetiology

  • Antiphospholipid syndrome
  • Thrombophilia
  • Balanced translocation (rare)
  • Uterine abnormality - associated with late first trimester losses
  • Independent risk factors - age and previous miscarriages

Management

  • Use of LDA and daily fragmin injections after confirmation of viable IUP in evidence of APS
  • Use of progesterone pessary in unexplained cases if age > 35 years and 2 or more losses